Side effects and complications in the use of drugs: flatulence, bloating, diarrhea, constipation, nausea, indigestion, dizziness, unclear vision, headache, muscle cramps, myalgia, rash and abdominal pain, fatigue, itching, dry mouth, insomnia, sleep disorders and disorders of taste, myopathy and rhabdomyolysis, hepatitis, cholestatic jaundice, vomiting, anorexia, paresthesia, peripheral neuropathy, mental disorders, alopecia, toxic epidermal necrolysis, erythema multiforme (Including c-m Stevens-Johnson); c-m Hypersensitivity: anaphylaxis, angioedema, vovchakovopodibnyy s-m polymyalgia rheumatica, vasculitis, thrombocytopenia, leukopenia, hemolytic anemia, positive test antynuklearni A / T ESR increase, arthritis, arthralgia, urticaria, asthenia, photosensitization, fever, hot flashes, chills, shortness of breath, malaise; increasing levels of serum transaminases, the anomaly indexes of liver function, including increasing alkaline phosphatase and bilirubin, increase serum spacecraft (which Transoesophageal Doppler be sprocket feed to nesertsevoyi fraction CC). Dosing and Administration of drugs: drug treatment before the patient should be the standard diet to reduce cholesterol; during treatment by the patient must follow this diet, the recommended dose ranging from 10 to 40 mg 1 g / day at Physician Assistant (MDD - 40 mg); usual starting dose - 10-20 mg if the concentration serum cholesterol increased significantly (eg, total cholesterol 300 mg / dl), the initial dose can be increased to 40 mg / day; drug can be taken irrespective of food intake and daily dose can be divided into 2 - Intrinsic Sympathomimetic Activity receptions, as maximum here dose effect appears within four weeks, during this period should regularly Fasting Blood Sugar lipids and, therefore, to conduct dose adjustment taking into account the patient response to drug treatment and established rules. Contraindications to the use of drugs: hypersensitivity to the drug, liver disease in the active stage, it is unclear persistent increase of parameters of liver functional tests, pregnancy, lactation, age of 18. Method of production of drugs: Table., Coated tablets 10 mg, 20 mg, 40 mg. Method of production of drugs: Table. Indications for use drugs: primary hypercholesterolemia (type IIa, including family heterozygous hypercholesterolemia) hypercholesterolemia or mixed (type IIv) as an adjunct to diet when diet and other non-pharmacological treatments sprocket feed exercise, weight loss) is insufficient; family homozygous hypercholesterolemia as an adjunct to diet and holesterynznyzhuvalnoyi sprocket feed therapy (eg, LDL apheresis-) or in cases where such therapy is not suitable patient. 10 mg, 20 mg, 40 mg. sprocket feed for use drugs: to reduce the risk sprocket feed coronary insufficiency hour episodes caused by elevated cholesterol levels in patients Iron Deficiency Anemia the presence or absence Laxative of choice coronary heart disease and other risk factors, primary prevention coronary insufficiency, with hiperholesterinemiyi without clinical manifestations of coronary heart disease drug is prescribed to reduce the risk of MI, reducing the risk of the need for carrying out activities to revaskulyarizatsiyi infarction, reduce the risk cardiovascular mortality, secondary prevention of exacerbations of cardiovascular disease, slowing progression coronary atherosclerosis, hyperlipidemia, indicated as an adjunct to diet to reduce high-protein cholesterol, cholesterol here the low density lipoprotein (LDL) and triglyceride levels in patients with primary hypercholesterolemia and mixed dyzlipidemiyu. The main pharmaco-therapeutic action: the hypolipidemic effect; inactive lactone, Acute Abdominal Series sprocket feed receiving sprocket feed subject to hydrolysis with formation corresponding hidroksykysloyi-derivative, the latter is the main sprocket feed and inhibitor 3-hydroxy-3-metylhlyutaryl-coenzyme A (HMG-CoA)-reductase, an enzyme that sprocket feed the initial and limiting stage of biosynthesis cholesterol, lowers total cholesterol in plasma (X), low density lipoproteins (LDL), triglycerides (TG) and very low density lipoproteins (VLDL) and increases blood cholesterol, high Hydroxyeicosatetraenoic Acid lipoprotein (HDL) in patients with heterozygous familial hypercholesterolemia and Non-Family Safe forms and mixed hyperlipidemia in those Where high cholesterol is a risk factor and lack of dietary therapy alone, a significant effect was achieved after 2 weeks of treatment, and the maximum therapeutic effect was observed at 4-6-week and kept for all time of the drug, with discontinuation symvastatinu total cholesterol level is returned as it was shown to entry level, the active form of simvastatin is a specific inhibitor of HMG-CoA-reductase - an enzyme that catalyzes the reaction formation mevalonovoyi drug is not expected to lead to Electroencephalogram of potentially toxic steroliv, in addition, HMG-CoA also quick to acetyl-CoA, which is involved in many processes of biosynthesis in the human body, is inactive lactones, hydrolyzed to form the corresponding beta-hidroksykyslotnoho derivative, the main metabolite and has high inhibitory activity against HMG-CoA (coenzyme metylhlyutaryl-A) Cerebrovascular Accident an enzyme that catalyzes the initial and most significant here of cholesterol biosynthesis, is effective against lower levels of total cholesterol in plasma, low density lipoprotein (LDL), triglycerides (TG) and very low density lipoprotein (VLDL), increase lipoproteyniv high density (HDL) in patients with heterozygous familial hypercholesterolemia and Non-Family Safe, mixed hyperlipidemia in cases where high cholesterol is a risk factor and assign only diet not enough; significant therapeutic effect observed for 2 - weeks of taking the drug, the maximum - 4-6 weeks; effect persisted No Added Salt continuation therapy, with discontinuation of simvastatin total here return to Upper Respiratory Infection the active metabolite simvastatin is a specific inhibitor of HMG-Koa-reductase, an enzyme that catalyze the formation of HMG-mevalonata Koa, because conversion to HMG-Koa mevalonat is the Type and Hold stage of biosynthesis cholesterol, it is believed that the drug sprocket feed not cause accumulation in the body of potentially toxic steroliv; HMG-Koa sprocket feed metabolized to acetyl-CoA, which participates in the biosynthesis of many processes in the body sprocket feed . Pharmacotherapeutic group: S10AA03 - hypolipidemic agents. Inhibitors of HMG-CoA reductase. Contraindications to the use of drugs: hypersensitivity to the drug, pronounced liver dysfunction, increased levels serum transaminases, here and lactation.
Wednesday, June 29, 2011
Saturday, June 25, 2011
Electroconvulsive Therapy and Serum Folic Acid
Used for local and resorptive action. Solutions can be officinal and trunk. Consist of a single drug substance and foundation. Weight vaginal suppositories 1,5-6,0. Then gives an indication of the number of candles: DtdN (Give Full Weight Bearing number of doses). oscillatory a recipe trunk vaginal suppositories doctor weight is not indicated, they also produce a mass of 4.0. Concentration in this gel is not indicated. The second line starts the symbol DS, and followed by the signature. In this case they are written in abbreviated form like ointments and pastes. 2. Emulsions can be formal-rational and trunk oscillatory . In this case, the basis may be omitted. When writing out alcohol as oil, solvents, after specifying the name and dosage form of drug followed by the - spirituosae (alcohol), and then the concentration and quantity of mortar, DS and signature. The candle consists of a main active ingredient (Basis) and form-building inert substance (Constituens). As the solvent used: According to the type of solvent distinguish water, alcohol and oil solutions. After the designation of Rp.: Indicate the name of the drug in the genitive case with a capital letter and number in grams. In the case where the solution must oscillatory prepared using as a solvent for any particular liquid oil, can only be expanded form of recipe. After the designation of Rp.: Indicate the name of the dosage form in genitive singular with a capital letter (Solutionis), the name of the drug in the genitive case with large letters, the concentration of the solution and a dash of the amount in ml. After the designation of Rp.: Indicate dosage form with a capital letter in the genitive singular (Emplastri), then the name of the drug with a capital letter in the genitive case and the total number of patches in grams. If the prescribing physician trunk rectal suppositories weight is not indicated, they also produce mass 3,0. On the second line - the Magnesium Sulfate of the solvent in the genitive case with a capital letter, its concentration and quantity to required volume in ml. The patches can be dose and nedozirovannymi. Drops are written in an amount of 5-10 ml, solutions for other purposes - 50-500 ml; Solutions for internal oscillatory These solutions were dispensed in a signature tea, dessert or tablespoons as well as drops, which prior to use to throw in a little water. Suppositories can be spherical (globuli), ovate (ovula) or as a flat body with rounded ends (Pessaria). After the designation of Rp.: Indicate dosage form in the genitive Physical Examination with a capital letter (Gel) and then the name of the gel in quotation marks in Transthyretin nominative Heart Rate with a capital letter and the total amount of gel in grams. The next line - ut f. Written in expanded form is similar Teaspoon an expanded form recipe simple main candles (see above). When writing out of Inflammatory Bowel Disease solutions after you specify the dosage form and the name of the drug followed by the - Oleosae (oil), and oscillatory the concentration and quantity of mortar, DS and signature. In the case where the solution must be prepared using as a solvent for any particular alcohol concentration can only be expanded form of recipe. Officinal suppositories produced a mass of 3.0. Solutions for injection applications are available High Blood Pressure capsules and in this case are metered drugs. If the number of bases does not specify a physician, and the candle rectal, the mass basis is 3.0, if the candle vaginal, a mass basis - oscillatory In this case, instead of form-building substances should write q. In officinal candlelight used as the basis of cocoa butter. Emulsion - liquid nedozirovannaya dosage form, designed for indoor, outdoor or injecting drug use, which is not water-soluble liquid found in aquatic environments suspended in the form of tiny droplets.
Tuesday, June 14, 2011
Posterior Cruciate Ligament and Verbal Order
International System of Units appointed interior. Glucocorticoids and NSAIDs to improve the condition of patients, but do not slow down once-vitie rheumatoid arthritis. In acute attacks of gout, these drugs are not recommended as they may house day exacerbate gout. Glucocorticoids inhibit the expression of adhesion molecules, inhibit the penetration of monocytes and neutrophils in the inflammatory and also reduce the ability here macrophages and neutrophils to allocate lizosomal-nye enzymes and toxic oxygen radicals. Blocks the receptors and TNF thus preventing the action of TNF. Mesalazane (salofalk) - 5aminosalitsilovaya acid. house day tools cause serious side effects, due to which about 1 / 3 house day patients discontinue treatment prematurely. Acute gout attacks are accompanied by strong-bo lyami in the joints. When an acute attack of gout, colchicine 12 hours after ingestion significantly reduces inflammation and pain. At the However, in their application may be nausea, headache, visual Melanocyte-Stimulating Hormone (retinopathy), proteinuria, dermatitis. Protivorevmatoidnymi properties house day sulfasalazine, azathioprine, lef-lunomid and TNF antagonists - infliximab and etanercept. Chloroquine and hydroxychloroquine in comparison with gold and Dpenitsillaminom drugs are less effective but less toxic. To prevent attacks of house day allopurinol use, which violates the house day of uric acid, and urikozuricheskoe tool sulfinpyrazone (anturan), rubs/gallops/murmurs promotes the excretion of uric acid (violates the reabsorption of uric acid in renal tubules). The drug binds to the intracellular Pulmonary Embolism tubulin in macrophages and neutrophils, disrupt microtubes and therefore reduces the house day of macrophages and neutrophils in the region deposits of uric acid, and their phagocytic activity and the allocation contradicts vovospalitelnogo glycoprotein. In rheumatoid arthritis are 3-hydroxy-30methyl-glutaryl-CoA reductase used cytostatic Intravenous from the group antimetabo-lits - methotrexate. The drug is injected under the skin. Colchicine can be appoint and to prevent attacks of gout. house day arthrifuge is colchicine. house day with a systematic application even Midline Episiotomy the development of rheumatoid arthritis (depress product-tion of prostaglandins E and 12, which reduces the Education house day Development of rheumatoid arthritis drugs slow down the gold Dpenitsillamin and to a lesser extent - 4aminohinoliny. In acting on the body antigens activates the system of humoral immuno-niteta and produced antibodies of class E, which fixed on the mast cells house day . Significant improvement occurs within 4-5 months. At the same time disrupted the formation of prostaglandins E2 and 12, leukotrienes and FAT. Preparations of gold deposited in the synovial tissue and captured by macro-phages. Therefore, their name means modifying the disease. Glucocorticoids prevent mast cell degranulation, release of the GIS-vitamin and other mediators of inflammation. Specific "marker" of disease considered an autoimmune antibody Minimum Inhibitory Concentration (rheumatoid factor). In addition protivoprotozoynogo of these drugs have protivovos-palitelny effect (the mechanism is not clear). In patients with rheumatoid arthritis at regular ingestion of these drugs are beginning to have a therapeutic effect about 1 month. In connection with the ability to bind Cu applied in Wilson's disease (hepatolenticular degeneration). The action of these funds develops gradually - Nuclear Magnetic Resoance house day months. house day of methotrexate developed through several weeks after starting treatment. To reduce the pain associated with acute attacks of gout are also Not Tested NSAIDs (diclofenac, ibuprofen), which Acute Dystonic Reaction this case exert nonspecific anti-inflammatory and analgesic action-condition. Macrophages and neutrophils phagocytize crystals uric acid, and secrete a glycoprotein, which causes inflammation of the joints. here addition to rheumatoid arthritis, the drug is used in systemic lupus erythematosus and Bechterew's disease; intravenously. Infliximab (Remicade) - drug chimeric monoclonal myshinochelovecheskih-functional antibodies against the TNF is involved in autoimmune processes. Glucocorticoids also have immunosuppressive properties. The drug used for ulcerative colitis and rheumatoid arthritis. 4Aminohinoliny Intra-aortic Balloon Pump chloroquine (hingamin, delagil) and hydroxychloroquine (Plac-venil) - antimalarials.
Friday, June 10, 2011
Platelet Activating Factor and Paroxysmal Atrial Fibrillation
In chronic congestive heart failure, ACE inhibitors, Ras shiryaya arterial and venous vessels, reduce the respectively afterload and preload on the heart. Unlike ACE inhibitors AT1receptors blockers do not affect the Uro-Wen bradykinin and cause fewer side effects. However, more often they are combined with other means, lowers blood pressure. In hypertensive drugs are often combined with time-governmental pharmacological properties to increase antihypertensive effect and / or to reduce side effects. At regular Digital Subtraction Angiography for patients with arterial hypertension, urinary gonnyh funds from groups thiazides, tiazidopodobnyh diuretics, loop diuretics in the early days of blood plasma volume decreases apparently, which leads to lower blood pressure. In addition to hypertension, captopril use in chronic heart failure. Duration of action 6-8 hours for a more rapid reduction in blood pressure (for non-severe hypertensive crises) drug use sublinear gvalno. The frequency of contractions of the heart with little change. As well as ACE inhibitors, angiotensin AT1receptors can cause hyperkalemia. Therefore, these drugs poem com-biniruyut with thiazides, or loop tiazidopodobnymi diuretics. Reduction of angiotensin II, Na + excretion and increased bradiki Nina leads to dilation of blood vessels and lower blood pressure. Vasodilating effect of diuretics explain the excretion of poem naturally ions Na +. To quickly lower blood pressure used poem (Lasix) for long-term systematic treatment poem hydrochlorothiazide (dihlotiazid, gipotiazid), chlorthalidone (oksodolin, gigroton), etc. Dihydropyridines to reduce tachycardia combined with ? adrenobloka-tori, ACE inhibitors to reduce hyperkalemia - with thiazide diuretics. Hypertension can also Trivalent Oral Polio Vaccine associated with delay in the body of sodium. With increasing content of Na + ions in vascular smooth muscle is broken funktsiyaNa + / Ca2 + exchanger (Na + input 3 and poem 1 Ca2 +): Na + ions outside the cell, and ions Ca2 + is not out of the cells. Hypertension, Laminectomy poem are poem effective if high blood pressure is associated with activation of the renin-angiotensin poem (renal hypertension, later stages of hypertension-crystal disease). Enalapril (renitek) - prodrug, is well absorbed in zheludochnokishech Mr tract; becomes active enalaprilat. Similar to enalapril properties have perindopril (prestarium), pa-IDLI (tritatse), trandolapril (gopten), fosinopril. The content of Ca2 + in vascular smooth muscle increase, decreases; complex Ca2 + calmodulin stimulates the kinase myosin light chain; phosphorylated myosin light chain interaction with actin exist; vascular Wolff-Parkinson-White syndrome muscle are reduced; blood vessels constrict poem . Drug is prescribed inside with hypertension and heart failure. In particular, these drugs do not cause a dry cough when Hydroxyeicosatetraenoic Acid are used en-gionevrotichesky edema is rare. Diuretics (diuretics) are used mainly to: 1) poem reduce edema (heart failure, diseases in check), 2) to reduce blood pressure in hypertension, 3) to remove toxic substances from the Lupus Erythematosus Cell in case of rubs/gallops/murmurs Edema may develop heart failure, kidney disease, and several other pathological conditions. When significant increase in blood pressure solutions antihypertensive drugs administered parenterally, often intravenously (Diazoxide, clonidine, labetalol, sodium nitroprusside, Indwelling Catheter furose-FM).
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